abstract：:The purpose of this study was to optimize the preparation method of injectable Octreotide microspheres. To explore the correlation between the solvent system and the general properties of microspheres to reduce burst release and enable them to be used for portal hypertension. Octreotide microspheres were prepared by m...

authors： Han B,Tang H,Liang Q,Zhu M,Xie Y,Chen J,Li Q,Jia J,Li Y,Ren Z,Cong D,Yu X,Sui D,Pei J

更新日期：2021-12-01 00:00:00

abstract：:Purpose: Despite increased focus on parenting support internationally, there is a lack of agreement in what constitutes parenting support. This paper explores the experiences of parenting support activities from the perspective of stakeholders in Norwegian basic schools.Methods: Five focus group interviews were conduc...

authors： Berg A,Appoh L,Ørjasæter KB

更新日期：2021-12-01 00:00:00

abstract：:The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway play a significant role in the production of inflammatory cytokines and type I interferons. This study aims to develop a cGAS-STING pathway-related genes (CSRs) prediction model to predict prognosis in gastric cancer (GC). In the present s...

authors： Yang KS,Xu CQ,Lv J

更新日期：2021-12-01 00:00:00

abstract：:Visfatin reportedly induces the expression of proinflammatory cytokines. Severe grades of intervertebral disc disease (IVDD) exhibit higher expression of visfatin than mild ones. However, the direct relationship between visfatin and IVDD remains to be elucidated. This study aimed to clarify whether stimulation of visf...

authors： Cui H,Du X,Liu C,Chen S,Cui H,Liu H,Wang J,Zheng Z

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:The response rate and survival benefit of immunotherapy vary among patients, implying specific immune status of an individual could be associated with the effect of immunotherapy. However, in-depth studies of immune subtypes (ISs), immune landscape and tumour microenvironment of oesophageal cancer (ESCA) and...

authors： Xie Y,Shi X,Chen Y,Wu B,Gong X,Lu W,Lin W

更新日期：2021-12-01 00:00:00

abstract：:Background: COVID-19 has rapidly become a major health emergency worldwide. The characteristic, outcome, and risk factor of COVID-19 in patients with decompensated cirrhosis remain unclear.Methods: Medical records were collected from 23 Chinese hospitals. Patients with decompensated cirrhosis and age- and sex-matched ...

authors： Xiao Y,Wu D,Shi X,Liu S,Hu X,Zhou C,Tian X,Liu H,Long H,Li Z,Wang J,Tan T,Xu Y,Chen B,Liu T,Zhang H,Zheng S,Hu S,Song J,Tang J,Song J,Cheng Z,Xu W,Shen Y,Yu W,Xu Y,Li J,Zhou J,Wang F,Chen M

更新日期：2021-12-01 00:00:00

abstract：:Purpose: This study examined what support cancer patients and their close ones need and how this support should be organized when developing cancer care pathways. The study focused on the opinions of professionals of the Cancer Society of Finland (CSF), who play a central role in presenting the third sector's perspect...

authors： Tiirola H,Poutanen VM,Vornanen R,Pylkkänen L

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:The relationship between sleeping disorders and chronic kidney disease (CKD) has already been reported. Snoring, a common clinical manifestation of obstructive sleep apnea-hypopnea syndrome, is of clinical value in assessing sleeping disorder severity. However, investigations of the connection between snorin...

authors： Jiang Z,Qin J,Liang K,Zhao R,Yan F,Hou X,Wang C,Chen L

更新日期：2021-12-01 00:00:00

abstract：:The current study aimed to investigate the effects of sodium butyrate on the level of colonic protein IRAK1 (interleukin-1 receptor-associated kinase 1) in irritable bowel syndrome (IBS) models as well as revealing the relationship between IRAKI level and visceral sensitivity during the progression of IBS. IBS symptom...

authors： He Y,Tan Y,Zhu J,Wu X,Huang Z,Chen H,Yang M,Chen D

更新日期：2021-12-01 00:00:00

abstract：:Dexamethasone has been widely used after various neurosurgical procedures due to its anti-inflammatory property and the abilities to restore vascular permeability, inhibit free radicals, and reduce cerebrospinal fluid production. According to the latest guidelines for the treatment of traumatic brain injury in the Uni...

authors： Niu F,Zhang B,Feng J,Mao X,Xu XJ,Dong JQ,Liu BY

更新日期：2021-12-01 00:00:00

abstract：:Fasudil, a Rho-associated protein kinase (ROCK) inhibitor, has a protective effect on the central nervous system. In addition, environmental enrichment is a promising technique for inducing the recovery of motor impairments in ischemic stroke models. The present study aimed to explore whether environmental enrichment ...

authors： Zhu YT,Zhang Q,Xie HY,Yu KW,Xu GJ,Li SY,Wu Y

更新日期：2021-12-01 00:00:00

abstract：:The term "menstrual health" has seen increased use across advocacy, programming, policy, and research, but has lacked a consistent, self-contained definition. As a rapidly growing field of research and practice a comprehensive definition is needed to (1) ensure menstrual health is prioritised as a unified objective in...

authors： Hennegan J,Winkler IT,Bobel C,Keiser D,Hampton J,Larsson G,Chandra-Mouli V,Plesons M,Mahon T

更新日期：2021-12-01 00:00:00

abstract：:Diacylglycerol kinase zeta (DGKZ) participates in cancer progression. Here, the current work aims to identify the functional role of DGKZ in cervical cancer (CC). DGKZ expression in cervical cancer tissues and paired adjacent normal cervical tissues was assessed using Immunohistochemistry assay. SiHa and HeLa cells we...

authors： Liu K,Xue B,Bai G,Zhang W

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:Due to the high perforation rate of cervical pedicle screw placement, we have designed four different types of rapid prototyping navigation templates to enhance the accuracy of cervical pedicle screw placement. METHODS:Fifteen human cadaveric cervical spines from C2 to C7 were randomly divided into five groups...

authors： Wen Z,Lu T,He X,Li J,Zang Q,Wang Y,Gao Z,Gu P

更新日期：2021-12-01 00:00:00

abstract：:As a common muscle relaxant, cisatracurium has shown good antitumor effect on some tumors. Recent studies reported that cisatracurium could inhibit the progression of colon cancer by upregulating tumor suppressor gene p53. However, its role in ovarian cancer and its regulatory effect on p53 and p53 downstream targetin...

authors： Zhu D,Shi C,Jiang Y,Zhu K,Wang X,Feng W

更新日期：2021-12-01 00:00:00

abstract：:The mitochondrial BKCa channel (mitoBKCa) is a splice variant of plasma membrane BKCa (Maxi-K, BKCa, Slo1, KCa1.1). While a high-resolution structure of mitoBKCa is not available yet, functional and structural studies of the plasma membrane BKCa have provided important clues on the gating of the channel by voltage and...

authors： González-Cota AL,Santana-Calvo C,Servín-Vences R,Orta G,Balderas E

更新日期：2021-12-01 00:00:00

abstract：:Continuous postoperative right and left ventricular diastolic pressures were measured in 12 consecutive patients undergoing pulmonic valvotomy and in 13 consecutive patients undergoing membranectomy and myectomy for discrete subaortic stenosis. All 25 patients had positive preoperative diastolic ventricular pressures....

authors： Hao W,Wang X,Fan J,Zeng Y,Ai H,Nie S,Wei Y

更新日期：2021-12-01 00:00:00

abstract：:Pemphigus and pemphigoid diseases are autoimmune bullous diseases characterized and caused by autoantibodies targeting adhesion molecules in the skin and/or mucous membranes. Personalized medicine is a new medical model that separates patients into different groups and aims to tailor medical decisions, practices, and ...

authors： Chen X,Li Y,Xu L,Sun Y,Politis C,Jiang X

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:To assess schizophrenia patients' approach toward coping with stress in terms of demographic variables. METHODS:The cross-sectional descriptive study was conducted at the State Hospital Community Mental Health Centre, Turkey, from November 1, 2013, to April 30, 2014 and comprised patients diagnosed with schi...

authors： Bah A,Nuotio I,Palomäki A,Mustonen P,Kiviniemi T,Ylitalo A,Hartikainen P,Airaksinen KEJ,Hartikainen JEK

更新日期：2021-12-01 00:00:00

abstract：:Senna spectabilis (DC.) H.S. Irwin & Barneby is a popular ornamental tree as well as a traditional medical plant in Cameroon. In this study, we sequenced and annotated the complete chloroplast genome of S. spectabilis and reconstructed the phylogenetic relationship of the tribe Cassieae. The length of the chloroplast ...

authors： Wang Q,Liu N,Ni YS,Yang JM,Ma L,Lan XB,Wu J,Niu JG,Yu JQ

更新日期：2021-12-01 00:00:00

abstract：:The role of autophagy and lysosomal degradation pathway in the regulation of skeletal muscle metabolism was previously studied. However, underlying molecular mechanisms are poorly understood. L-lactate which is utilized as an energetic substrate by skeletal muscle can also augment genes expression related to metabolis...

authors： Dudas S,Anderson R,Staskevicus A,Mitchell G,Cross JC,Czub S

更新日期：2021-12-01 00:00:00

abstract：:Due to the specific properties of the marine environment, marine microorganisms have exclusive physicochemical characteristics that are different from those of terrestrial microorganisms, which can produce various secondary metabolites (SMs) with considerable structural diversity and biological activity. In this study...

authors： Fomina AF,Nguyen HM,Wulff H

更新日期：2021-12-01 00:00:00

abstract：SUMMARY:The genetic basis of youthfulness is poorly understood. The aging of skin depends on both intrinsic factors and extrinsic factors. Intrinsic factors include personal genetics, and extrinsic factors include environmental exposure to solar radiation and pollution. We recently reported the critical role of the mit...

authors： Wang Q,Zhao Z,Shen H,Bing Q,Li N,Hu J

更新日期：2021-12-01 00:00:00

abstract：SUMMARY:The genetic basis of youthfulness is poorly understood. The aging of skin depends on both intrinsic factors and extrinsic factors. Intrinsic factors include personal genetics, and extrinsic factors include environmental exposure to solar radiation and pollution. We recently reported the critical role of the mit...

authors： Taniguchi-Ponciano K,Vadillo E,Mayani H,Gonzalez-Bonilla CR,Torres J,Majluf A,Flores-Padilla G,Wacher-Rodarte N,Galan JC,Ferat-Osorio E,Blanco-Favela F,Lopez-Macias C,Ferreira-Hermosillo A,Ramirez-Renteria C,Peña-Martínez E,

更新日期：2021-12-01 00:00:00

abstract：:Benign prostatic hyperplasia (BPH) is a disorder related to hormone imbalance, local angiogenesis, and prostate growth, which can be treated surgically (orchiectomy) or medically (most commonly with finasteride). However, finasteride therapy is not completely established in dogs regarding local action and posology. Th...

authors： Li Y,Yin Y,Peng X,Zheng H,Fu F,Liu Z,Wu X,Wu X,Zheng S,Chen N,He L,Ren L,Ni Z,Li D,Liang P,Lv X,Zhang Y

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:The SARS-CoV-2 pandemic has led to drastic changes in how psychiatric consultation-liaison (C-L) services conduct business and required rapid transition to telepsychiatry. We describe the practice changes implemented to rapid transition to virtual care in a large, academic psychiatry C-L service in response ...

authors： Montera M,Goins A,Cmarko L,Weiss N,Westlund KN,Alles SRA

更新日期：2021-12-01 00:00:00

abstract：:Metrnl, a secreted protein expressed in white adipose tissue, has been identified as a novel adipokine. It is also highly expressed in barrier tissues, including the skin, intestinal and respiratory tract epithelium in both mice and humans. Research shows that its expression is upregulated by inflammation, chronic hig...

authors： Halalau A,Imam Z,Karabon P,Mankuzhy N,Shaheen A,Tu J,Carpenter C

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:The study aimed to present a family with myoclonus dystonia (M-D) syndrome due to a mutation in the epsilon sarcoglycan gene (SGCE). Three members of the family suffered from treatment-refractory severe myoclonic jerks of the neck, trunk, and upper extremities. The mild dystonic symptoms recognized as cervic...

authors： Creed S,Walsh E,Foley T

更新日期：2021-12-01 00:00:00

abstract：:Process management is defined as the concept of identifying processes in a company or healthcare organization, analyzing them and improving productivity and efficiency. In hospitals, process management focuses on patient safety, an increase in economic resources and employee satisfaction. The integration of process ma...

authors： Wang J,Cong X,Miao M,Yang Y,Zhang J

更新日期：2021-12-01 00:00:00

abstract：:The ability to identify specific HLA molecules against which a patient has alloantibodies has revolutionized assessment of immunologic compatibility. Anti-HLA antibodies are typically evaluated as reactive against well-defined serologic antigen groups. Thus, donor HLA genotyping is aimed at defining HLA at the serolog...

authors： Yao T,Song G,Li Y,Wang D

更新日期：2021-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is a chronic neurodegenerative disease that has been recognized as one of the most intractable medical problems with heavy social and economic costs. Amyloid-β (Aβ) has been identified as a major factor that participates in AD progression through its neurotoxic effects. The major mechanism of ...

authors： Zhang H,Yang Y,Huang J,Lailan S,Tao X

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Troponin composition characterization has been implicated as a next step to differentiate among non-ST elevation myocardial infarction (NSTEMI) patients and improve distinction from other conditions with troponin release. We therefore studied coronary and peripheral troponin compositions in relation to clini...

authors： Li G,Zhang C,Liang W,Zhang Y,Shen Y,Tian X

更新日期：2021-12-01 00:00:00

abstract：:A simple, efficient, environmentally friendly, and inexpensive synthesis route was developed to obtain a magnetic nano-hybrid (GH) based on graphene and cobalt ferrite. Water with a high content of natural organic matter (NOM) was used as solvent and a source of carbon. The presence of NOM in the composition of GH was...

authors： Medehouenou TCM,Roy C,Tremblay PY,St-Jean A,Meziou S,Muckle G,Ayotte P,Lucas M

更新日期：2021-12-01 00:00:00

abstract：:The regulatory circuitry underlying embryonic stem (ES) cell self-renewal is well defined, but how this circuitry is disintegrated to enable lineage specification is unclear. RNA-binding proteins (RBPs) have essential roles in RNA-mediated gene regulation, and preliminary data suggest that they might regulate ES cell ...

authors： Tkaczyk M,Gadomska-Prokop K,Załuska-Leśniewska I,Musiał K,Zawadzki J,Jobs K,Porowski T,Rogowska-Kalisz A,Jander A,Kirolos M,Haliński A,Krzemień A,Sobieszczańska-Droździel A,Zachwieja K,Beck BB,Sikora P,Zaniew M

更新日期：2021-12-01 00:00:00

abstract：:The regulatory circuitry underlying embryonic stem (ES) cell self-renewal is well defined, but how this circuitry is disintegrated to enable lineage specification is unclear. RNA-binding proteins (RBPs) have essential roles in RNA-mediated gene regulation, and preliminary data suggest that they might regulate ES cell ...

authors： Chen JB,Li LC,Lee WC,Moi SH,Yang CH

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Mindfulness-based interventions (MBIs) can alleviate psychological distress in patients with cancer. However, face-to-face MBIs may be inconvenient for patients. Therefore, guided self-help interventions may be more accessible. The authors investigated the effects of a guided self-help MBI for depression, an...

authors： Yu IC,Liu CY,Fang JT

更新日期：2021-12-01 00:00:00

abstract：:Quantum dots (QDs) are nanoparticles of inorganic semiconductors and have great promise in various applications. Many studies have indicated that mitochondria are the main organelles for the distribution and toxic effects of QDs. However, the underlying mechanism of QDs interacting with mitochondria and affecting thei...

authors： Huang F,Wang L,Zhang Q,Wan Z,Hu L,Xu R,Cheng A,Lv Y,Liu Q

更新日期：2021-12-01 00:00:00

abstract：:Background: Women face contradictions regarding their health: Pressure to be feminine, but also athletic; Criticism for being too sporty or muscular, but equally so for being perceived as lazy or overweight. These complexities are perpetuated through media and discourse. Purpose: Using a feminist post-structural appro...

authors： Spencer RA,Numer M,Rehman L,Kirk SFL

更新日期：2021-12-01 00:00:00

abstract：:We previously reported that disruption of the yjbI gene reduced virulence of Staphylococcus aureus. In this study, we found virulence in both silkworms and mice was restored by introducing the yjbH gene but not the yjbI gene to both yjbI and yjbH genes-disrupted mutants, suggesting that yjbH, the gene downstream to th...

authors： Paudel A,Panthee S,Hamamoto H,Grunert T,Sekimizu K

更新日期：2021-12-01 00:00:00

abstract：:Previous studies reported that miR-330-3p was involved in the progression of several cancers, but the potential roles of miR-330-3p in ovarian cancer (OC) were unclear. In the current study, we aimed to explore the expression pattern and functions of miR-330-3p in OC. The expression level of miR-330-3p in OC tissues a...

authors： Cai L,Ye L,Hu X,He W,Zhuang D,Guo Q,Shu K,Jie Y

更新日期：2021-12-01 00:00:00